Phospho-NF1 (Ser2515) Polyclonal Antibody
Product Specifications
Background
Neurofibromin is a product of the tumor suppressor gene, Neurofibromatosis type I. Neurofibromin is known to have GTPase activity that modulates the ras pathway. The absence of or alteration of the neurofibromin protein may lead to Neurofibromatosis disease. This protein has not been purified, therefore, most of the information regarding this protein has been deduced from homology analysis of its gene sequence.
CAS Number
9007-83-4
Structure Composition
0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Product Name Alternative
NF1 (phospho S2515) ; NF1 (phospho Ser2515) ; p-NF1 (S2515) ; DKFZp686J1293; FLJ21220; Neurofibromatosis Noonan syndrome; Neurofibromatosis related protein NF 1; Neurofibromatosis related protein NF1; neurofibromatosis type I; Neurofibromatosis-related protein NF-1; Neurofibromin 1; Neurofibromin truncated; Neurofibromin1; NF 1; NF; NF1; NF1_HUMAN; NFNS; Type 1 Neurofibromatosis; von Recklinghausen disease neurofibromin; von Recklinghausen disease related protein VRNF; VRNF; WATS; Watson disease related protein WSS; Watson syndrome; WSS.
Swiss Prot
P21359
Reactivity
Human, Mouse, Rat, Horse, Rabbit
Immunogen
KLH conjugated Synthesised phosphopeptide derived from human NF1 around the phosphorylation site of Ser2515:QT (p-S) PR
Conjugation
Unconjugated
Applications
IHC-P
Dilution
IHC-P=1:100-500
Purity
Affinity purified by Protein A
Modification
Phosphorylation
Molecular Weight
147/319kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Phospho-NF1 (Ser2515) Polyclonal Antibody detects endogenous levels of NF1 protein only when phosphorylated at Ser2515.
Applications Notes
Paraformaldehyde-fixed, paraffin embedded (Mouse brain) ; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (phospho-NF1 (Ser2515) ) Polyclonal Antibody, Unconjugated at 1:400 overnight at 4°C
Host or Source
Rabbit
Available Sizes
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