DAB2 Polyclonal Antibody
Product Specifications
Background
This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Abbreviation
DAB2
UniProt
P98082
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Recombinant protein of human DAB2
Target
DAB 2; Dab; mitogen-responsive phosphoprotein; homolog 2 (Drosophila) ; DAB2; Differentially expressed in ovarian cancer 2; Differentially expressed protein 2; Disabled (Drosophila) homolog 2 (mitogen responsive phosphoprotein) ; Disabled homolog 2; Disabled homolog 2 mitogen responsive phosphoprotein (Drosophila) ; Disabled homolog 2 mitogen responsive phosphoprotein; Disabled; Drosophila; homolog of;2; DOC 2; DOC2; FLJ26626; Mitogen responsive phosphoprotein
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB; IHC
Field of Research
Cancer; Epigenetics and Nuclear Signaling; Signal Transduction
Purification
Affinity purification
Concentration
0.6 mg/mL
Dilution
WB 1:500-1:2000; IHC 1:50-1:200
Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Product Datasheet
https://789.bio/ea/1xe5dl
Product MSDS
https://789.bio/eb/T4arfP
Calculated Molecular Weight
82kDa
Isotype
IgG
Available Sizes
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