Fbx32 Polyclonal Antibody
Product Specifications
Background
Fbx32 is an E3 ubiquitin ligase that initiates ATP dependent ubiquitin-mediated proteolysis and promotes muscle atrophy. It is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. It is also thought to recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation during skeletal muscle atrophy. Fbx32 interacts with MyoD by ubiquitination via a sequence found in transcriptional coactivators and therefore may play an important role in the course of muscle differentiation by determining the abundance of MyoD.
CAS Number
9007-83-4
Structure Composition
0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Product Name Alternative
Fbx32; 4833442G10Rik; AI430017; Atrogin 1; Atrogin-1; ATROGIN1; Atrophy gene 1; F box only protein 32; F-box only protein 32; F-box protein 32; FBX32_HUMAN; fbxo25; FBXO32; FLJ32424; MAFbx; MGC108443; MGC137646; MGC33610; Muscle atrophy F box; Muscle atrophy F box protein; Muscle atrophy F-box protein.
Swiss Prot
Q969P5
Reactivity
Human, Rat, (predicted: Mouse, Dog, Pig, Cow, Horse, Rabbit, )
Immunogen
KLH conjugated synthetic peptide derived from human MAFbx:31-130/355
Conjugation
Unconjugated
Applications
FCM
Dilution
Flow-Cyt=2ug/Test
Purity
Affinity purified by Protein A
Modification
Unmodification
Molecular Weight
42kD
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Fbx32 Polyclonal Antibody detects endogenous levels of Fbx32 protein.
Host or Source
Rabbit
Available Sizes
Curated Selection
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