MADCAM1 polyclonal antibody
Product Specifications
Background
The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin family and is similar to ICAM1 and VCAM1. At least seven alternatively spliced transcripts encoding different protein isoforms have been found for this gene, but the full-length nature of some variants has not been determined.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
MADCAM1; MACAM1
Swiss Prot
Q13477
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human MADCAM1 (NP_570116.2) .
Conjugation
Unconjugated
Applications
WB IHC
Dilution
WB 1:200 - 1:1000 IHC 1:50 - 1:100
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 45 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
MADCAM1 polyclonal antibody detects endogenous levels of MADCAM1 protein.
Applications Notes
Western blot analysis of extracts of various cell lines, using MADCAM1 antibody at 1:1000 dilution.
Host or Source
Rabbit
Available Sizes
Frequently Asked Questions
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