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CD81 monoclonal antibody

Product Specifications

Background

CD81 belongs to the tetraspanin family, which is characterized by four transmembrane domains, one short extracellular domain (ECL1), and one long extracellular domain (ECL2) . Tetraspanins interact with a variety of cell surface proteins and intracellular signaling molecules in specialized tetraspanin enriched microdomains (TEMs) where they mediate a range of processes including adhesion, motility, membrane organization, and signal transduction . CD81, like other tetraspanins, is enriched in exosomes . Many research studies demonstrate a role for CD81 in lymphocyte signaling . CD81 is also a well-characterized receptor for Hepatitis C Virus and facilitates the entry of the virus into target cells .

CAS Number

9007-83-4

Structure Composition

Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Product Name Alternative

TAPA1; TSPAN28; CD81 antigen; 26 kDa cell surface protein TAPA-1; Target of the antiproliferative antibody 1; Tetraspanin-28; Tspan-28; CD81

Swiss Prot

P60033

Reactivity

Human, Rat

Immunogen

Recombinant fusion protein of human CD81. The exact sequence is proprietary.

Conjugation

Unconjugated

Applications

WB

Dilution

WB (1/500 - 1/1000), IHC (1/100 - 1/500)

Purity

This antibody is purified through a protein G column.

Modification

Unmodification

Molecular Weight

~ 22 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

Recognizes endogenous levels of CD81 protein.

Applications Notes

Western blot analysis of CD81 expression in A549 (A), Ramos (B), U87 MG (C) whole cell lysates.

Host or Source

Mouse

Available Sizes

Frequently Asked Questions

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