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MTHFD2 monoclonal antibody

Product Specifications

Background

MTHFD2 is a bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase involved in mitochondrial folate metabolism . MTHFD2 expression is developmentally regulated, as it is expressed in embryos but not in most adult tissues. Recent research studies have shown that MTHFD2 is consistently overexpressed in many cancer types and correlated with poor survival in breast cancer . Overexpression of MTHFD2 promotes cell proliferation while its depletion induces cell death in human cancer cells .

CAS Number

9007-83-4

Structure Composition

Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Product Name Alternative

NMDMC; Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial

Swiss Prot

P13995

Reactivity

Human, Mouse

Immunogen

KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human MTHFD2. The exact sequence is proprietary.

Conjugation

Unconjugated

Applications

WB

Dilution

WB (1/1000 - 1/2000)

Purity

This antibody is purified through a protein G column.

Modification

Unmodification

Molecular Weight

~ 40 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

Recognizes endogenous levels of MTHFD2 protein.

Applications Notes

Western blot analysis of MTHFD2 expression in Hela (A), 293 (B), MOLT4 (C), mouse heart (D) whole cell lysates.

Host or Source

Mouse

Available Sizes

Frequently Asked Questions

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