Phospho-GCN2 (Thr667) polyclonal antibody
Product Specifications
Background
This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. The encoded protein responds to amino acid deprivation by binding uncharged transfer RNAs. It may also be activated by glucose deprivation and viral infection. Mutations in this gene have been found in individuals suffering from autosomal recessive pulmonary venoocclusive-disease-2.
CAS Number
9007-83-4
Structure Composition
50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Product Name Alternative
GCN2-like protein; GCN2; KIAA1338; EIF2AK4
Swiss Prot
Q9P2K8
Reactivity
Human
Immunogen
A synthetic phosphopeptide corresponding to residues surrounding Thr667 of human GCN2
Conjugation
Unconjugated
Applications
WB, IP
Dilution
WB: 1/500-1/1000 IP: 1/20
Purity
Affinity Purified
Modification
Phosphorylated
Molecular Weight
Calculated MW: 187 kDa; Observed MW: 220 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
IgG
Applications Notes
Western blot analysis of Phospho-GCN2 in Hela, HepG2, 293T lysates using Phospho-GCN2 antibody.
Host or Source
Rabbit
Available Sizes
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