Lin28B Mouse Monoclonal Antibody [A2-4-5]
LIN28 is thought to regulate the self-renewal of stem cells. In nematodes, the LIN28 homolog lin-28 is a heterochronic gene that determines the onset of early larval stages of developmental events in Caenorhabditis elegans, by regulating the self-renewal of nematode stem cells in the skin (called seam cells) and vulva (called VPCs) during development. In mice, LIN28 is highly expressed in mouse embryonic stem cells and during early embryogenesis.It acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Lin28B is high expression in testis, fetal liver, placenta and in hepatocellular carcinoma (HCC).
Product Specifications
CAS Number
9007-83-4
Product Name Alternative
Abbreviation
Lin-28B
Swiss Prot
Q6ZN17 Human
Cellular Locus
Cytoplasm, nucleus
Host
Mouse
Species Reactivity
Human
Immunogen
Recombinant protein within Human Lin28B aa 73-250 / 250.
Isotype
IgG2a
Conjugation
Non-conjugated
Type
Mouse monoclonal Antibody
Applications
WB, IF-Cell, IHC-P
Positive Control
JAR cell lysate, NCCIT, human placenta tissue.
Concentration
2 mg/mL
Dilution
WB: 1:1,000 ;IF-Cell: 1:100-1:200 ;IHC-P: 1:1,000
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 27 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
No
Frequently Asked Questions
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