DBCO-PEG4-amine
Product Specifications
UNSPSC Description
DBCO-PEG4-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-PEG4-amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-PEG4-amine can be used in the synthesis of FPM-PEG4-DBCO (a homobifunctional azide-to-azide cross-linker)[1]. DBCO-PEG4-amine is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
Target Antigen
ADC Linker; PROTAC Linkers
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related;PROTAC
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dbco-peg4-amine.html
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(NCCOCCOCCOCCOCCN)CCC(N1C2=CC=CC=C2C#CC3=CC=CC=C3C1)=O
Molecular Weight
523.62
References & Citations
[1]Florinas S, et al. A Nanoparticle Platform To Evaluate Bioconjugation and Receptor-Mediated Cell Uptake Using Cross-Linked Polyion Complex Micelles Bearing Antibody Fragments. Biomacromolecules. 2016 May 9;17(5):1818-33.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-130435/DBCO-PEG4-amine-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-130435/DBCO-PEG4-amine-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1840886-10-3
Available Sizes
Curated Selection
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