DBCO-PEG4-amine

DBCO-PEG4-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-PEG4-amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . DBCO-PEG4-amine can be used in the synthesis of FPM-PEG4-DBCO (a homobifunctional azide-to-azide cross-linker) [1]. DBCO-PEG4-amine is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

Product Specifications

CAS Number

[1840886-10-3]

UNSPSC

12352203

Hazard Statement

H302, H315, H319, H335

Target

ADC Linker; PROTAC Linkers

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dbco-peg4-amine.html

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(NCCOCCOCCOCCOCCN)CCC(N1C2=CC=CC=C2C#CC3=CC=CC=C3C1)=O

Molecular Formula

C29H37N3O6

Molecular Weight

523.62

Precautions

H302, H315, H319, H335

References & Citations

[1]Florinas S, et al. A Nanoparticle Platform To Evaluate Bioconjugation and Receptor-Mediated Cell Uptake Using Cross-Linked Polyion Complex Micelles Bearing Antibody Fragments. Biomacromolecules. 2016 May 9;17 (5) :1818-33.