TIP3 Antibody / SOCS1 / SSI1
Suppressor of cytokine signaling 1 (SOCS1), also known as Jak-binding protein (JAB) and Tec-interacting protein 3 (TIP3), is a negative regulator to a subset of protein-tyrosine kinases. This 211-amino acid protein has a molecular mass of about 23.5 kD. The TEC-binding region of SOCS1 resides in the N terminus. SOCS1 associates with Tec and suppresses its kinase activity. The SOCS1 gene is intronless and is mapped to on chromosome 16p13.13. SOCS1 regulates the JAK/STAT signal-transduction pathway. Moreover, it contributes to protection against hepatic injury and fibrosis, and may also protect against hepatocarcinogenesis.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Immunohistochemistry (FFPE) : 2-5 µg/mL
UniProt
O15524
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Amino acids FLVRDSRQRNCFFALSVKMA were used as the immunogen for the TIP3 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Reconstitution
Limitations
This TIP3 antibody is available for research use only.
Storage Conditions
Product Datasheet
https://www.nsjbio.com/tds-pdf/tip3-antibody-socs1-ssi1-rq7255
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the TIP3 antibody should be determined by the researcher.
Location
Nucleus, cytoplasmic vesicles
Image Legend
IHC staining of FFPE human lung cancer tissue with TIP3 antibody. HIER: boil tissue sections in pH8 EDTA for 20 min and allow to cool before testing.
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