DMT-2'-F-dC (Bz) -CE-Phosphoramidite
DMT-2'-F-dC (Bz) -CE-Phosphoramidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Product Specifications
CAS Number
[182495-83-6]
UNSPSC
12352005
Hazard Statement
H302-H315-H319
Target
Nucleoside Antimetabolite/Analog
Type
Oligonucleotides
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dmt-2-f-dc-bz-ce-phosphoramidite.html
Solubility
10 mM in DMSO
Smiles
F[C@@H]1[C@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@@H](COC(C2=CC=C(C=C2)OC)(C3=CC=CC=C3)C4=CC=C(C=C4)OC)O[C@H]1N5C=C(C)C(NC(C6=CC=CC=C6)=O)=NC5=O
Molecular Formula
C47H53FN5O8P
Molecular Weight
865.92
Precautions
P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501
References & Citations
[1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18 (23) :3373-88.
Shipping Conditions
Room temperature
Scientific Category
Oligonucleotides
Clinical Information
No Development Reported
Available Sizes
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