Recombinant Human Cyclophilin A Protein
Product Specifications
Background
Peptidyl-prolyl cis-trans isomerase A is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family; which catalyzes the cis-trans isomerization of proline imidic peptide bonds. Cyclophilin A regulate many biological processes; including intracellular signaling; transcription; inflammation; and apoptosis. Cyclophilin is also incorporated into many viruses; including HIV1; where it has been speculated to be involved in functions such as viral assembly and infectivity. The immunosuppressive activity of cyclosporins has been correlated with their ability to form complexes with cyclophilins that inhibit calcineurin phosphatase activity and prevent incorporation of cyclophilin into viral particles. The cyclosporin/cyclophilin complex selectively binds and inactivates calcineurin; making it a useful inhibitor for studying calcineurin activity.
Abbreviation
Cyclophilin A
Synonyms
CYPA ; Cyclophilin A; Cyclosporin A-binding protein; PPIA; PPIase A; Peptidyl-prolyl cis-trans isomerase A; Rotamase A; SP18
UniProt
P62937
Accession Number
P62937
Expression System
E.coli
Tag
None
Sequence
Met 1-Glu165
Field of Research
Signal Transduction; immunology
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
18.0 kDa
Observed Molecular Weight
16 kDa
Formulation
Supplied as a 0.2 μm filtered solution of PBS, 10% Glycerol, pH 7.4.
Species
Human
Available Sizes
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