TASP0277308
TASP0277308 is a highly selective S1P1 antagonist. TASP0277308 possesses immunomodulatory activities, including lymphopenia, a block in T cell egress from the thymus, marginal zone B cell displacement, and the upregulation of CD69 expression on lymphocytes. TASP0277308 can be used for the research of collagen-induced arthritis in mice[1].
Product Specifications
CAS Number
945725-50-8
UNSPSC
12352005
Target
LPL Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tasp0277308.html
Purity
99.00
Solubility
10 mM in DMSO
Smiles
CCN1C(OC2=CC(N3CCN(CC3)C)=CC=C2)=NN=C1[C@@H](C)NS(=O)(C4=CC(Cl)=C(C=C4)Cl)=O
Molecular Formula
C23H28Cl2N6O3S
Molecular Weight
539.48
References & Citations
[1]Fujii Y, et al. Amelioration of collagen-induced arthritis by a novel S1P1 antagonist with immunomodulatory activities. J Immunol. 2012 Jan 1;188 (1) :206-15.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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