TLR4 Antibody [TLR4/230]
Product Specifications
Background
This mAb reacts with human Toll-like receptor 2 (TLR4) . It is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene.
NCBI Gene ID
7099
Swiss Prot
O00206
Host
Mouse
Reactivity
Human, Monkey, Pig, Dog, Rat, Guinea Pig
Immunogen
Recombinant human protein was used as the immunogen for the TLR4 antibody.
Clonality
Monoclonal
Clone
TLR4/230
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Innate Immunity, Inflammasomes
Purification
Protein G affinity chromatography
Concentration
0.2 mg/mL
Buffer
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=33-472
Fragment
IgG2a, kappa
Applications Notes
1. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 min.
Symbol
TLR4
NCBI Official Name
Toll-like receptor 4
NCBI Organism
Homo sapiens
Other Product Names
TLR4 Antibody: TOLL, CD284, TLR-4, ARMD10, Toll-like receptor 4, hToll
Tested Applications
Functional Assays, Flow, IF, IHC-P
Physical Properties
Liquid
Curated Selection
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