BET-IN-23
Bet-in-23 (Compound 23) is a BD2-selective BET inhibitor with an IC50 of 2.9 nM. BET-IN-23 has anticancer activity and can significantly inhibit the proliferation of acute myeloid leukemia (AML) cell lines by inducing G0/G1 arrest and apoptosis in vitro[1].
Product Specifications
CAS Number
2953287-57-3
UNSPSC
12352005
Target
Apoptosis; Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Apoptosis; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bet-in-23.html
Solubility
10 mM in DMSO
Smiles
CN1C=C(C(NCC(N2CCOCC2)=O)=CC1=O)C3=C(C=CC(C(C)(O)C)=C3)OC4=C(C=C(C=C4C)F)C
Molecular Formula
C29H34FN3O5
Molecular Weight
523.60
References & Citations
[1]Jiang W, et al. Discovery of Novel Phenoxyaryl Pyridones as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with High Selectivity for the Second Bromodomain (BD2) to Potentially Treat Acute Myeloid Leukemia. J Med Chem. 2024 Jan 4.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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