JE-133

JE-133 is an optically active isochromane-2H-chromene conjugate. JE-133 exhibits antioxidant and anti-inflammatory activities. JE-133 is a neuroprotective agent that effectively inhibits neuronal oxidative damage associated with PI3K/Akt and MAPK signaling pathways. JE-133 can also inhibit lipopolysaccharide (LPS) (HY-D1056) -induced neuroinflammation by regulating JAK/STAT and Nrf2 signaling pathways[1][2].

Product Specifications

CAS Number

[2579171-69-8]

UNSPSC

12352005

Target

Akt; p38 MAPK; PI3K

Type

Reference compound

Related Pathways

MAPK/ERK Pathway; PI3K/Akt/mTOR

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/je-133.html

Solubility

10 mM in DMSO

Smiles

CCOC([C@@H]1C([C@H]2C3=CC(O)=C(O)C=C3C[C@H](O2)C)=CC4=CC(OC)=CC=C4O1)=O

Molecular Formula

C23H24O7

Molecular Weight

412.43

References & Citations

[1]Tao L, et al. JE-133 Suppresses LPS-Induced Neuroinflammation Associated with the Regulation of JAK/STAT and Nrf2 Signaling Pathways[J]. ACS Chemical Neuroscience, 2024.|[2]Tao L, et al. An optically active isochroman-2 H-chromene conjugate potently suppresses neuronal oxidative injuries associated with the PI3K/Akt and MAPK signaling pathways[J]. Acta Pharmacologica Sinica, 2021, 42 (1) : 36-44.