Phospho-MEK1/2 (Ser221) Rabbit PE Conjugate

<strong>Phospho-MEK1/2 (Ser221) Rabbit PE Conjugate</strong>_x000D_ <strong>Catalog number:</strong> B2018524_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 25 ug_x000D_ <strong>Molecular Weight or Concentration:</strong> N/A_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> 2-8°C_x000D_ <strong>Keywords:</strong> Dual specificity mitogen-activated protein kinase kinase 1/2, MAPK/ERK kinase 1, MAPKK1, MAPKK2, MAP2K1, MAP2K2, PRKMK1, PRKMK2_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Guo Y, Kamara S, Zhang J, Wen H, Zheng M, Liu Y, Zhou L, Chen J, Zhu S, Zhang L. EBV LMP1-C terminal binding affibody molecule downregulates MEK/ERK/p90RSK pathway and inhibits the proliferation of nasopharyngeal carcinoma cells in mouse tumor xenograft models Front Cell Infect Microbiol. 2023 Jan 4;12:1078504._x000D_ 2: Kovalenko D, Yang X, Nadeau RJ, Harkins LK, Friesel R. Sef inhibits fibroblast growth factor signaling by inhibiting FGFR1 tyrosine phosphorylation and subsequent ERK activation J Biol Chem. 2003 Apr 18;278(16):14087-91._x000D_ 3: Fu DT, Tu J, Cai YQ, Cai ZW, Zhang LZ, Liu JY, Xu SC, Wang DJ. [The regulatory mechanism of Raf/MEK/ERK pathway on the rat cardiac hypertrophy induced by transverse aortic constriction] Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2020 Jan 28;36(1):33-38._x000D_ 4: Bekdash A, Darwish M, Timsah Z, Kassab E, Ghanem H, Najjar V, Ghosn M, Nasser S, El-Hajj H, Bazerbachi A, Liu S, Leppla SH, Frankel AE, Abi-Habib RJ. Phospho-MEK1/2 and uPAR Expression Determine Sensitivity of AML Blasts to a Urokinase-Activated Anthrax Lethal Toxin (PrAgU2/LF) Transl Oncol. 2015 Oct;8(5):347-357._x000D_ 5: Song H, Zhang J, Ning L, Zhang H, Chen D, Jiao X, Zhang K. The MEK1/2 Inhibitor AZD6244 Sensitizes BRAF-Mutant Thyroid Cancer to Vemurafenib Med Sci Monit. 2018 May 8;24:3002-3010._x000D_ 6: Xiao L, Pimental DR, Amin JK, Singh K, Sawyer DB, Colucci WS. MEK1/2-ERK1/2 mediates alpha1-adrenergic receptor-stimulated hypertrophy in adult rat ventricular myocytes J Mol Cell Cardiol. 2001 Apr;33(4):779-87._x000D_ 7: Wu X, Li L. Rosiglitazone suppresses lipopolysaccharide-induced matrix metalloproteinase-2 activity in rat aortic endothelial cells via Ras-MEK1/2 signaling Int J Cardiol. 2012 Jun 28;158(1):54-8._x000D_ 8: Brown CN, Atwood DJ, Pokhrel D, Ravichandran K, Holditch SJ, Saxena S, Miyazaki M, Nemenoff R, Weiser-Evans MCM, Ljubanovic DG, Joy MS, Edelstein CL. The effect of MEK1/2 inhibitors on cisplatin-induced acute kidney injury (AKI) and cancer growth in mice Cell Signal. 2020 Jul;71:109605._x000D_ 9: Adams DG, Coffee RL Jr, Zhang H, Pelech S, Strack S, Wadzinski BE. Positive regulation of Raf1-MEK1/2-ERK1/2 signaling by protein serine/threonine phosphatase 2A holoenzymes J Biol Chem. 2005 Dec 30;280(52):42644-54._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/24606810">10: Cheng CY, Lin JG, Su SY, Tang NY, Kao ST, Hsieh CL. Electroacupuncture-like stimulation at Baihui and Dazhui acupoints exerts neuroprotective effects through activation of the brain-derived neurotrophic factor-mediated MEK1/2/ERK1/2/p90RSK/bad signaling pathway in mild transient focal cerebral ischemia in rats BMC Complement Altern Med. 2014 Mar 7;14:92. </a>_x000D_ _x000D_ <strong>Products Related to Phospho-MEK1/2 (Ser221) Rabbit PE Conjugate can be found at</strong> <a href="https://moleculardepot.com/product-category/Conjugates/"> Conjugates</a>