Anticancer agent 177

Anticancer agent 177 (Compound 11b) is a NAMPT inhibitor and DNA alkylating agent. Anticancer agent 177 has antitumor activity in vitro and in vivo[1].

Product Specifications

CAS Number

[9007-83-4]

UNSPSC

12352005

Target

DNA Alkylator/Crosslinker; NAMPT

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/anticancer-agent-177.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC=CC(N(CCCl)CCCl)=C1)N2CCC(CC2)CCCCNC(/C=C/C3=CN=CC=C3)=O

Molecular Formula

C28H36Cl2N4O2

Molecular Weight

531.52

References & Citations

[1]Fu Y, et al. Discovery of Dual Function Agents That Exhibit Anticancer Activity via Catastrophic Nicotinamide Adenine Dinucleotide Depletion. J Med Chem. 2023 Dec 7.