PBX-7011 (mesylate)
PBX-7011 mesylate is an active Camptothecin derivative. PBX-7011 can bind to the DDX5 protein in cells, thereby inducing cell death through DDX5 protein degradation[1].
Product Specifications
UNSPSC
12352203
Target
Survivin
Type
ADC Related
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pbx-7011-mesylate.html
Solubility
10 mM in DMSO
Smiles
OS(=O)(C)=O.N[C@@H]1C2=C3C(C=C4C(OCO4)=C3CC1)=NC5=C2CN6C5=CC7=C(COC([C@]7(O)CC)=O)C6=O
Molecular Formula
C25H25N3O9S
Molecular Weight
543.55
References & Citations
[1]Jung DY, et al. Camptothecin derivatives that bind to ddx5 protein and prodrugs thereof. WO2023204631A1. 2023-10-26.
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
Frequently Asked Questions
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