RORγt agonist 4
RORγt agonist 4 (compound 14) is a potent and selective agonist of RORγt. RORγt agonist 4 significantly enhances metabolic stability. RORγt agonist 4 improves the situation of tumor models of mouse B16F10 melanoma and LLC lung adenocarcinoma[1].
Product Specifications
CAS Number
[2241769-59-3]
UNSPSC
12352005
Target
ROR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/rorγt-agonist-4.html
Solubility
10 mM in DMSO
Smiles
N#CC1=C(OC(C)C)C=CC(C2=C(C=C(NC(CC3=CC=C(S(=O)(CC)=O)C=C3)=O)C=C2Cl)Cl)=C1
Molecular Formula
C26H24Cl2N2O4S
Molecular Weight
531.45
References & Citations
[1]Lu L, et al. Discovery of Biaryl Amide Derivatives as Potent, Selective, and Orally Bioavailable RORγt Agonists for Cancer Immunotherapy. J Med Chem. 2023 Nov 20.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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