ZM640
ZM640 is a NLRP3 inhibitor. ZM640 enhances IL-1β release mediated by NLRP3 inflammasome activation in THP-1 cells. ZM640 shows low cytotoxicity[1].
Product Specifications
UNSPSC
12352005
Target
NOD-like Receptor (NLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/zm640.html
Solubility
10 mM in DMSO
Smiles
O=S(NCC[C@H]1[C@H](CC2)[C@@H](O)[C@@]([C@@]3(O)[C@@H](O)[C@]4([H])C(C)(C)CC5)(C1=O)[C@]2([H])[C@]4(CO3)[C@H]5O)(C6=CC=C(C=C6)C(F)(F)F)=O
Molecular Formula
C28H36F3NO8S
Molecular Weight
603.65
References & Citations
[1]Li M, et al. Discovery of novel oridonin sulfamide derivatives as potent NLRP3 inhibitors by a visible-light photocatalysis-enabled peripheral editing. Bioorg Med Chem Lett. Published online January 18, 2024.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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