DHFR-IN-11

DHFR-IN-11 (compound 6b) is inhibitor of DHFR, and has inhibitory potency versus M. tuberculosis DHFR enzyme with IC50 values 5.70 μM[1].

Product Specifications

UNSPSC

12352005

Target

Dihydrofolate reductase (DHFR)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/dhfr-in-11.html

Solubility

10 mM in DMSO

Smiles

O=C1N=C(N2N=C(C3=CC=CS3)CC2C4=CC(OC)=CC=C4OC)SC1

Molecular Formula

C18H17N3O3S2

Molecular Weight

387.48

References & Citations

[1]Dawood DH, et, al. New Thiophenyl-pyrazolyl-thiazole Hybrids as DHFR Inhibitors: Design, Synthesis, Antimicrobial Evaluation, Molecular Modeling, and Biodistribution Studies. ACS Omega. 2023 Oct 13;8 (42) :39250-39268.|[2]Dawood DH, et al. New Thiophenyl-pyrazolyl-thiazole Hybrids as DHFR Inhibitors: Design, Synthesis, Antimicrobial Evaluation, Molecular Modeling, and Biodistribution Studies. ACS Omega. 2023;8 (42) :39250-39268. Published 2023 Oct 13.