DHFR-IN-8
DHFR-IN-8 (compound 6r) is a dihydrofolate reductase (DHFR) inhibitor that affects purine and thymidylate biosynthesis in cell proliferation and growth. DHFR-IN-8 inhibits methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300 (IC50=15.6 ng/mL) in mouse models of systemic infection and thigh infection[1].
Product Specifications
CAS Number
3032441-09-8
UNSPSC
12352005
Target
Bacterial; Dihydrofolate reductase (DHFR)
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/dhfr-in-8.html
Solubility
10 mM in DMSO
Smiles
NC1=NC2=C(C(N)=N1)C(C=CN3CC4=CC=C5SC=NC5=C4)=C3C=C2
Molecular Formula
C18H14N6S
Molecular Weight
346.41
References & Citations
[1]Zhu Z, et al. Exploration and Biological Evaluation of 1, 3-Diamino-7 H-pyrrol [3, 2-f] quinazoline Derivatives as Dihydrofolate Reductase Inhibitors[J]. Journal of Medicinal Chemistry, 2023.. . .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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