5-HT6R antagonist 1
5-HT6R antagonist 1 (Comopund 8) is a 5-HT6R antagonist (Ki: 5 nM). 5-HT6R antagonist 1 inhibits platelet aggregation. 5-HT6R antagonist 1 has excellent metabolic stability. 5-HT6R antagonist 1 reverses MK-801 -induced memory impairments in rats. 5-HT6R antagonist 1 can be used for Alzheimer's disease (AD) research[1].
Product Specifications
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/5-ht6r-antagonist-1.html
Solubility
10 mM in DMSO
Smiles
NC1=NC(C(OC2=CC(F)=CC=C2F)CC)=NC(N3CCN(C)CC3)=N1
Molecular Formula
C17H22F2N6O
Molecular Weight
364.39
References & Citations
[1]Sudoł-Tałaj S, et al. Hydrophobicity modulation via the substituents at positions 2 and 4 of 1,3,5-triazine to enhance therapeutic ability against Alzheimer's disease for potent serotonin 5-HT6R agents. Eur J Med Chem. 2023 Nov 15;260:115756.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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