SPC-180002

SPC-180002 is a SIRT1/3 dual inhibitor, with IC50 values of 1.13 and 5.41 μM, respectively. SPC-180002 disturbs redox homeostasis via ROS generation, which leads to an increase in both p21 protein stability and mitochondrial dysfunction. SPC-180002 strongly inhibits cell cycle progression and cancer cell growth. SPC-180002 activates the Nrf2 signaling pathway[1].

Product Specifications

CAS Number

[2170274-53-8]

UNSPSC

12352005

Target

Keap1-Nrf2; Reactive Oxygen Species (ROS) ; Sirtuin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/spc-180002.html

Solubility

10 mM in DMSO

Smiles

O=C(C(CN(CCC1=CC=CC=C1)CC(C(OC)=O)=C)=C)OC

Molecular Formula

C18H23NO4

Molecular Weight

317.38

References & Citations

[1]Cho Y, et al. SPC-180002, a SIRT1/3 dual inhibitor, impairs mitochondrial function and redox homeostasis and represents an antitumor activity. Free Radic Biol Med. 2023 Aug 2;208:73-87.