BuChE-IN-9
BuChE-IN-9 (compound 22a) is a potent equine serum-derived BuChE (eqBuChE) inhibitor with an IC50 of 173 nM. BuChE-IN-9 also inhibits human BACE1, Aβ aggregation, mouse GABA transporter 1 (mGAT1) and mGAT4. BuChE-IN-9 has significant antiamnesic properties[1].
Product Specifications
UNSPSC
12352005
Target
Beta-secretase; Cholinesterase (ChE) ; GABA Receptor
Type
Natural Products
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/buche-in-9.html
Solubility
10 mM in DMSO
Smiles
CN(C(CCN)C(NCC1=CC=CC=C1)=O)CCOCCN2C(C=CC=C3)=C3C4=C2C=CC=C4
Molecular Formula
C28H34N4O2
Molecular Weight
458.60
References & Citations
[1]Paula Zaręba, et al. Discovery of novel multifunctional ligands targeting GABA transporters, butyrylcholinesterase, β-secretase, and amyloid β aggregation as potential treatment of Alzheimer's disease. Eur J Med Chem. 2023 Oct 7:261:115832.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Frequently Asked Questions
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