MK-8768
MK-8768 is a highly potent, orally bioavailable and selective class of mGluR2 negative allosteric modulator (IC50 of 9 .6nM) with excellent brain permeability.
Product Specifications
CAS Number
1432729-22-0
UNSPSC
12352005
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/mk-8768.html
Solubility
10 mM in DMSO
Smiles
NC(C1=NC2=CC(CN3C[C@H](C(F)(F)F)O[C@H](C)C3)=CC=C2C(C4=CN(C)N=C4)=C1)=O
Molecular Formula
C21H22F3N5O2
Molecular Weight
433.43
References & Citations
[1]Michael T. Rudd, et al. Discovery of MK-8768, a Potent and Selective mGluR2 Negative Allosteric Modulator. ACS Med. Chem. Lett.. 2023, 14, 8.|[2]Sean M Smith, et al. The novel phosphodiesterase 10A inhibitor THPP-1 has antipsychotic-like effects in rat and improves cognition in rat and rhesus monkey.Neuropharmacology, 2013 Jan;64:215-23.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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