Nav1.3 channel inhibitor 1

Nav1.3 channel inhibitor 1 (compound 15b) is a state-dependent voltage-gated sodium channel Nav1.3 inhibitor (IC50=20 nM) . Nav1.3 channel inhibitor 1 can penetrate the blood-brain barrier and can be used in the research of nervous system diseases[1].

Product Specifications

UNSPSC

12352005

Target

Sodium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/nav1-3-channel-inhibitor-1.html

Solubility

10 mM in DMSO

Smiles

O=C(C1C(C2=CC=C(F)C(F)=C2)C1)NC3=CC=C(S(=O)(NC4=NC=CS4)=O)C=C3

Molecular Formula

C19H15F2N3O3S2

Molecular Weight

435.47

References & Citations

[1]Zidar N, et al. New aryl and acylsulfonamides as state-dependent inhibitors of Nav1.3 voltage-gated sodium channel. Eur J Med Chem. 2023 Oct 5;258:115530.