Nav1.3 channel inhibitor 1
Nav1.3 channel inhibitor 1 (compound 15b) is a state-dependent voltage-gated sodium channel Nav1.3 inhibitor (IC50=20 nM) . Nav1.3 channel inhibitor 1 can penetrate the blood-brain barrier and can be used in the research of nervous system diseases[1].
Product Specifications
UNSPSC
12352005
Target
Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nav1-3-channel-inhibitor-1.html
Solubility
10 mM in DMSO
Smiles
O=C(C1C(C2=CC=C(F)C(F)=C2)C1)NC3=CC=C(S(=O)(NC4=NC=CS4)=O)C=C3
Molecular Formula
C19H15F2N3O3S2
Molecular Weight
435.47
References & Citations
[1]Zidar N, et al. New aryl and acylsulfonamides as state-dependent inhibitors of Nav1.3 voltage-gated sodium channel. Eur J Med Chem. 2023 Oct 5;258:115530.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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