3’-Azido-N6-benzoyl-3’-deoxyadenosine
Product Specifications
UNSPSC Description
3’-Azido-N6-benzoyl-3’-deoxyadenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. 3’-Azido-N6-benzoyl-3’-deoxyadenosine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Target Antigen
Nucleoside Antimetabolite/Analog
Type
Oligonucleotides
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/3-azido-n6-benzoyl-3-deoxyadenosine.html
Solubility
10 mM in DMSO
Smiles
OC[C@@H]1[C@@H](N=[N+]=[N-])[C@@H](O)[C@H](N2C(N=CN=C3NC(C4=CC=CC=C4)=O)=C3N=C2)O1
Molecular Weight
396.36
References & Citations
[1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-154579/3-Azido-N6-benzoyl-3-deoxyadenosine-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-154579/
Clinical Information
No Development Reported
CAS Number
103597-10-0
Curated Selection
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