Casanthranol

Casanthranol is a concentrated mixture of anthranol glycosides from cascara sagrada (dried bark of Rhamnus p.) . Casanthranol can be used as a laxative in constipation and various medical conditions, stimulant laxative. Casanthranol encourages bowel movements by acting on the intestinal wall to increase muscle contractions. Casanthranol is protective in a PFF-induced toxicity model (EC50 = 34.2 μM) of N2a cells[1][2].

Product Specifications

CAS Number

[8024-48-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Others

Type

Natural Products

Related Pathways

Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/Casanthranol.html

Solubility

DMSO : ≥ 50 mg/mL

Smiles

[Casanthranol]

Precautions

H302, H315, H319, H335

References & Citations

[1]NCIt. Casanthranol.|[2]Braun, A. R., et al., (2023) . Advancements in a FRET Biosensor for Live-Cell Fluorescence-Lifetime High-Throughput Screening of Alpha-Synuclein. ASN neuro, 15, 17590914231184086.