2'-O-Me-5-I-U-3'-phosphoramidite
2’-O-Me-5-I-U-3’-phosphoramidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Product Specifications
UNSPSC
12352005
Target
Nucleoside Antimetabolite/Analog
Type
Oligonucleotides
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/2-o-me-5-i-u-3-phosphoramidite.html
Solubility
10 mM in DMSO
Smiles
COC(C=C1)=CC=C1C(C2=CC=C(OC)C=C2)(C3=CC=CC=C3)OC[C@@H]4[C@@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@@H](OC)[C@H](N5C(NC(C(I)=C5)=O)=O)O4
Molecular Formula
C40H48IN4O9P
Molecular Weight
886.71
References & Citations
[1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18 (23) :3373-88.
Shipping Conditions
Room temperature
Scientific Category
Oligonucleotides
Clinical Information
No Development Reported
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
GTF2IRD2B, CT (GTF2IRD2B, General transcription factor II-I repeat domain-containing protein 2B, Transcription factor GTF2IRD2-beta) (FITC) discontinued
Human NADH-ubiquinone oxidoreductase 75 kDa subunit, NDUFS1 ELISA KIT
RAPGEF5 (GFR, KIAA0277, MRGEF, Rap Guanine Nucleotide Exchange Factor 5, Guanine Nucleotide Exchange Factor for Rap1, M-Ras-regulated Rap GEF, Related to Epac)
