RUNX1T1 Mouse Monoclonal Antibody [Clone ID: LBI1H1]

Product Specifications

Background

This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t (8;21) (q22; q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq]

Overview

Carrier-free (BSA/glycerol-free) RUNX1T1 mouse monoclonal antibody, clone LBI1H1

Synonyms

AML1T1; CBFA2T1; CDR; ETO; MTG8; ZMYND2

Gene Name

Homo sapiens RUNX1 partner transcriptional co-repressor 1 (RUNX1T1), transcript variant 3, mRNA.

Gene ID

862

UniProt

Q06455

Conjugation

Unconjugated

Related Pathways

Acute myeloid leukemia, Pathways in cancer

Field of Research

Acute myeloid leukemia, Pathways in cancer

Dilution

WB 1:2000, IF 1:100

Form

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Buffer

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Function

Transcription Factors

Storage Conditions

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.