Anivamersen (sodium)

Anivamersen sodium is an RNA aptamer to reverse the anticoagulant effect of the parenteral factor IXa inhibitor pegnivacogin. REG1 is a novel anticoagulation system consisting of pegnivacogin, an RNA aptamer inhibitor of coagulation factor IXa, and anivamersen, a complementary sequence reversal oligonucleotide.

Product Specifications

CAS Number

[959716-31-5]

UNSPSC

12352208

Target

Factor Xa

Type

Oligonucleotides

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/anivamersen-sodium.html

Solubility

10 mM in H2O

Smiles

[Anivamersen(sodium)]

Molecular Formula

C157H194N56Na14O103P14

Molecular Weight

5269.10

References & Citations

[1]Lincoff AM, Mehran R, Povsic TJ, et al. Effect of the REG1 anticoagulation system versus bivalirudin on outcomes after percutaneous coronary intervention (REGULATE-PCI) : a randomised clinical trial [published correction appears in Lancet. 2016 Mar 19;387 (10024) :1162. Boudoulas, Dean [corrected to Boudoulas, Konstantinos D.]]. Lancet. 2016;387 (10016) :349-356. doi:10.1016/S0140-6736 (15) 00515-2