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ASK1-IN-4

ASK1-IN-4 (Compound 17) is an ASK1 inhibitor (IC50=0.2 μM) . ASK1-IN-4 interacts with ATP-binding site of ASK1[1].

Product Specifications

CAS Number

1427538-26-8

UNSPSC

12352005

Target

Apoptosis; ASK1; MAP3K

Type

Reference compound

Related Pathways

Apoptosis; MAPK/ERK Pathway

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ask1-in-4.html

Solubility

10 mM in DMSO

Smiles

BrC(C=C1)=CC=C1C2=CC=C(O2)/C=C3C(N(C(S/3)=S)CCCC(O)=O)=O

Molecular Formula

C18H14BrNO4S2

Molecular Weight

452.34

References & Citations

[1]Starosyla SA, et al. ASK1 pharmacophore model derived from diverse classes of inhibitors. Bioorg Med Chem Lett. 2014 Sep 15;24 (18) :4418-4423.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

MAP3K5/ASK1

Frequently Asked Questions

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