ASK1-IN-4
ASK1-IN-4 (Compound 17) is an ASK1 inhibitor (IC50=0.2 μM) . ASK1-IN-4 interacts with ATP-binding site of ASK1[1].
Product Specifications
CAS Number
[1427538-26-8]
UNSPSC
12352005
Target
Apoptosis; ASK1; MAP3K
Type
Reference compound
Related Pathways
Apoptosis; MAPK/ERK Pathway
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ask1-in-4.html
Solubility
10 mM in DMSO
Smiles
BrC(C=C1)=CC=C1C2=CC=C(O2)/C=C3C(N(C(S/3)=S)CCCC(O)=O)=O
Molecular Formula
C18H14BrNO4S2
Molecular Weight
452.34
References & Citations
[1]Starosyla SA, et al. ASK1 pharmacophore model derived from diverse classes of inhibitors. Bioorg Med Chem Lett. 2014 Sep 15;24 (18) :4418-4423.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAP3K5/ASK1
Curated Selection
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