Fmoc-DON-Boc
Product Specifications
UNSPSC Description
Fmoc-DON-Boc (Compound 8b) is an Fmoc-protected compound that can be used for the synthesis of proagent of 6-diazo-5-oxo-L-norleucine (DON; HY-108357). DON is a glutamine antagonist[1].
Target Antigen
Drug Intermediate
Type
Reference compound
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fmoc-don-boc.html
Solubility
10 mM in DMSO
Smiles
CC(C)OC([C@H](CCC(C=[N+]=[N-])=O)NC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O)=O
Molecular Weight
435.47
References & Citations
[1]Rais R, et al. Discovery of 6-Diazo-5-oxo-l-norleucine (DON) Prodrugs with Enhanced CSF Delivery in Monkeys: A Potential Treatment for Glioblastoma. J Med Chem. 2016 Sep 22;59(18):8621-33.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-153151/Fmoc-DON-Boc-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-153151/
Clinical Information
No Development Reported
CAS Number
1998724-98-3
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