L-162537

L-162537 is a competitive human angiotensin II receptor 1 (AT1) and receptor 2 (AT2) antagonist with an IC50=1.7 nM for AT1. L-162537 inhibits Ang II-mediated vasoconstriction, blood pressure elevation and related pathological signaling pathways. L-162537 is promising for research of angiotensin II-related cardiovascular diseases such as hypertension[1].

Product Specifications

CAS Number

[167027-99-8]

UNSPSC

12352005

Target

Angiotensin Receptor

Related Pathways

GPCR/G Protein

Field of Research

Cardiovascular Disease

Smiles

CCCC1=NC2=C(C(N1CC3=CC=C(C4=C(C5=NNN=N5)C=CC=C4)C=C3)=O)C=C(N(CC6=CN=CC=C6)C(C7=CC=CC=C7)=O)C=C2

Molecular Formula

C38H32N8O2

Molecular Weight

632.71

References & Citations

[1]de Laszlo S E, et al. The SAR of 6- (N-alkyl-N-acyl) -2-propyl-3-[ (2′-tetrazol-5-yl) biphen-4-yl) methyl]-quinazolinones as balanced affinity antagonists of the human AT1 and AT2 receptors[J]. Bioorganic & Medicinal Chemistry Letters, 1995, 5 (13) : 1359-1364.