GZ-11608
GZ-11608 is a potent and selective vesicular monoamine transporter-2 (VMAT2) inhibitor with high affinity (Ki = 25 nM) . GZ-11608 decreases methamphetamine-induced dopamine release from isolated synaptic vesicles from brain dopaminergic neurons. GZ-11608 exhibits rapid brain penetration and without neurotoxicity. GZ-11608 can be used for the research of methamphetamine use disorder[1].
Product Specifications
CAS Number
2141974-01-6
UNSPSC
12352005
Target
Monoamine Transporter
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/gz-11608.html
Solubility
10 mM in DMSO
Smiles
C[C@H](NCCCC1=CC=C(OC)C=C1)CC2=CC=CC=C2
Molecular Formula
C19H25NO
Molecular Weight
283.41
References & Citations
[1]Lee NR, et al. GZ-11608, a Vesicular Monoamine Transporter-2 Inhibitor, Decreases the Neurochemical and Behavioral Effects of Methamphetamine. J Pharmacol Exp Ther. 2019 Nov;371 (2) :526-543.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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