Tubulin inhibitor 31
Tubulin inhibitor 31 is a potent tubulin inhibitor with an IC50 value of 4 μM. Tubulin inhibitor 31 shows anti-proliferative activity. Tubulin inhibitor 31 inhibits the HUVEC migration[1].
Product Specifications
UNSPSC
12352005
Target
Microtubule/Tubulin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/tubulin-inhibitor-31.html
Solubility
10 mM in DMSO
Smiles
COC1=CC=C(C=C1)CN2C=C(C3=C2C=CC=C3)C4=CC=C(C=C4)O
Molecular Formula
C22H19NO2
Molecular Weight
329.39
References & Citations
[1]Prudhomme V, et al. Design, synthesis and biological evaluation of conformationnally-restricted analogues of E7010 as inhibitors of tubulin assembly (ITA) and vascular disrupting agents (VDA) . Eur J Med Chem. 2022 Dec 15;244:114809.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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