Funalenone

Funalenone (BMS-304245) is a MraY + MurG inhibitor with an IC50 of 25.5 μM in a MraY + MurG membrane plate assay. Funalenone inhibits Staphylococcus aureus (A15090) with an MIC of 64 μg/mL. Funalenone also inhibits MMP-1 with an IC50 of 170 μM[1][2].

Product Specifications

CAS Number

[259728-61-5]

Product Name Alternative

BMS-304245

UNSPSC

12352005

Hazard Statement

H302+H312+H332

Target

Bacterial; HIV Integrase; MMP

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/funalenone.html

Solubility

10 mM in DMSO

Smiles

O=C1C(OC)=C(O)C2=C3C1=C(O)C=C(O)C3=C(C)C=C2O

Molecular Formula

C15H12O6

Molecular Weight

288.25

Precautions

H302+H312+H332

References & Citations

[1]J Inokoshi, et al. Funalenone, a novel collagenase inhibitor produced by Aspergillus niger. J Antibiot (Tokyo) . 1999 Dec;52 (12) :1095-100. |[2]Kazuro Shiomi, et al. Fungal phenalenones inhibit HIV-1 integrase. J Antibiot (Tokyo) . 2005 Jan;58 (1) :65-8. |[3]Zawadzke LE, et al. Targeting the MraY and MurG bacterial enzymes for antimicrobial therapeutic intervention. Anal Biochem. 2003 Mar 15;314 (2) :243-52.|[4]Inokoshi J, et al. Funalenone, a novel collagenase inhibitor produced by Aspergillus niger. J Antibiot (Tokyo) . 1999 Dec;52 (12) :1095-100.