PBRM1-BD2-IN-6
PBRM1-BD2-IN-6 is a potent PBRM1 bromodomain inhibitor with an IC50 value of 0.22 μM. PBRM1-BD2-IN-6 shows antiproliferation activity. PBRM1-BD2-IN-6 has the potential for the research of PBRM1-dependent cancer[1].
Product Specifications
CAS Number
[2819989-67-6]
UNSPSC
12352005
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pbrm1-bd2-in-6.html
Solubility
10 mM in DMSO
Smiles
O=C1NC(C2=CC=CC(C)=C2C)NC3=C1C(Cl)=CC=C3
Molecular Formula
C16H15ClN2O
Molecular Weight
286.76
References & Citations
[1]Shishodia S, et al. Selective and Cell-Active PBRM1 Bromodomain Inhibitors Discovered through NMR Fragment Screening. J Med Chem. 2022 Oct 13.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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