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HIF-1/2α-IN-1

HIF-1/2α-IN-1 is an orally active HIF-2α inhibitor. HIF-1/2α-IN-1 inhibits HIF-2α activity with an IC50 value of 0.92 μM. HIF-1/2α-IN-1 also can decrease HIF-1α levels. HIF-1/2α-IN-1 can be used for the research of clear cell renal cell carcinoma (ccRCC) [1].

Product Specifications

CAS Number

2827693-99-0

UNSPSC

12352005

Target

HIF/HIF Prolyl-Hydroxylase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hif-1-2α-in-1.html

Solubility

10 mM in DMSO

Smiles

COC1=CC=C(C=C1OC)C2=NN=C(O2)NC3=NC4=C(N3)C=CN=C4OC

Molecular Formula

C17H16N6O4

Molecular Weight

368.35

References & Citations

[1]Yangsook Song Green, et al. ISCA2 inhibition decreases HIF and induces ferroptosis in clear cell renal carcinoma. Oncogene. 2022 Sep 12.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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