JAK-2/3-IN-2
JAK-2/3-IN-2 (Compound 3h) is a JAK2 and JAK3 inhibitor with IC50s of 23.85 nM and 18.9 nM, respectively[1].
Product Specifications
CAS Number
2170398-48-6
UNSPSC
12352005
Target
JAK
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/jak-2-3-in-2.html
Solubility
10 mM in DMSO
Smiles
O=C1N(C2=CC=CC=C2Cl)N(CC)C(C)=C1SC3=CC=C(C)C=C3
Molecular Formula
C19H19ClN2OS
Molecular Weight
358.88
References & Citations
[1]Sanachai K, et al. Pharmacophore-Based Virtual Screening and Experimental Validation of Pyrazolone-Derived Inhibitors toward Janus Kinases. ACS Omega, 2022.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
JAK2; JAK3
Frequently Asked Questions
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