HBChE-IN-2
HBChE-IN-2 (compound 15d) is a butyrylcholinesterase (BChE) inhibitor (IC50 of 0.62 μM) and a cannabinoid receptor 2 (CB2R) agonist. hBChE-IN-2 has neuroprotection activities[1].
Product Specifications
CAS Number
2923366-36-1
UNSPSC
12352005
Target
Cannabinoid Receptor; Cholinesterase (ChE)
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/hbche-in-2.html
Solubility
10 mM in DMSO
Smiles
O=C(N(C)C)OC1=CC=C(CC2=NC3=C(N2CCC(C)C)C=CC(C(N(CC)CC)=O)=C3)C=C1
Molecular Formula
C27H36N4O3
Molecular Weight
464.60
References & Citations
[1]Philipp Spatz, et al. Dual-Acting Small Molecules: Subtype-Selective Cannabinoid Receptor 2 Agonist/Butyrylcholinesterase Inhibitor Hybrids Show Neuroprotection in an Alzheimer's Disease Mouse Model. J Med Chem. 2023 May 11;66 (9) :6414-6435.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BChE; CB2
Available Sizes
Frequently Asked Questions
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