Recombinant Mouse REG3B/Pap1 Protein (His Tag)
Product Specifications
Background
Expression of REG3B was sufficient to inhibit cytokine-induced activation of STAT3 in IECs. The human REG3beta protein, the functional counterpart of mouse REG3B, inhibited STAT3 activity in human 293T cells, and its expression level in colorectal tumors correlated inversely with pSTAT3 level and survival times of patients. REG3B negatively regulates cytokine-induced activation of STAT3 in colon epithelial cells. This pathway might be targeted in patients with colitis to reduce carcinogenesis.
Synonyms
HIP; PAP1; Pap; REG-III
UniProt
P35230
Accession Number
NP_035166.1
Expression System
HEK293 Cells
Tag
C-His
Sequence
Met1-Gly175
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Product Datasheet
https://789.bio/ea/lta5z1
Product MSDS
https://789.bio/eb/WDi1iH
Calculated Molecular Weight
18.1 kDa
Observed Molecular Weight
19 kDa
Species
Mouse
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