Ack1 inhibitor 1

Ack1 inhibitor 1 is a potent, selective, and orally active inhibitor of ACK1 kinase with an IC50 value of 2.1 nM. Ack1 inhibitor 1 inhibits the phosphorylation of ACK1 and activation of downstream AKT. Ack1 inhibitor 1 has anti-tumor activity[1].

Product Specifications

CAS Number

[2924415-92-7]

UNSPSC

12352005

Target

Ack1; Akt

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ack1-inhibitor-1.html

Solubility

10 mM in DMSO

Smiles

CN(CC1)CCN1C(C=C2)=CC(OCC)=C2NC3=NC=C4C(N(C[C@@H]5OCCC5)C(C(C6=CC(NC(C7=CC(C(F)(F)F)=CC=C7)=O)=CC=C6)=C4)=O)=N3

Molecular Formula

C39H40F3N7O4

Molecular Weight

727.77

References & Citations

[1]Li Q, et al. Design, Synthesis, and Evaluation of (R) -8- ((Tetrahydrofuran-2-yl) methyl) pyrido[2,3-d]pyrimidin-7-ones as Novel Selective ACK1 Inhibitors to Combat Acquired Resistance to the Third-Generation EGFR Inhibitor. J Med Chem. 2023 May 25;66 (10) :6905-6921.