AD186
Product Specifications
UNSPSC Description
AD186 is a potent and selective S1R agonist with Kis of 2.7, 27 nM for S1R and S2R, respectively. AD186 fully reverses the antiallodynic effect of BD-1063 (HY-18101A)[1].
Target Antigen
Sigma Receptor
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ad186.html
Solubility
10 mM in DMSO
Smiles
N1(CCC2=CC=CC=C2)CC3(CCN(CC4=CC=CC=C4)CC3)C1
Molecular Weight
320.47
References & Citations
[1]Dichiara M, et al. Synthesis, Computational Insights, and Evaluation of Novel Sigma Receptors Ligands. ACS Chem Neurosci. 2023 May 17;14(10):1845-1858.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-149853/AD186-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-149853/
Clinical Information
No Development Reported
Curated Selection
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