MTHFD2-IN-4
MTHFD2-IN-4, tricyclic coumarin derivative, is a potent MTHFD2 inhibitor. MTHFD2-IN-4 can be used in research of cancer[1].
Product Specifications
UNSPSC
12352005
Target
Methylenetetrahydrofolate Dehydrogenase (MTHFD)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mthfd2-in-4.html
Solubility
10 mM in DMSO
Smiles
O=C1OC2=C(C3=C1CN(CC3)C(C4=CC=C(C=C4)C([O-])(C(F)(F)F)C(F)(F)F)=O)C=CC(C5CNCCO5)=C2
Molecular Formula
C26H21F6N2O5-
Molecular Weight
555.45
References & Citations
[1]Jha V, et, al. Binding Analysis and Structure-Based Design of Tricyclic Coumarin-Derived MTHFD2 Inhibitors as Anticancer Agents: Insights from Computational Modeling. ACS Omega. 2023 Apr 12;8 (16) :14440-14458.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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