HPK1-IN-40-d2
HPK1-IN-40 (compound 49) is a potent and selective HPK1 inhibitor with an IC50 of 0.9 nM. HPK1-IN-40 reinvigorates T-cell receptor (TCR) signaling, promoting T-cell function and cytokine production in T cells while having anti-cancer activity[1].
Product Specifications
UNSPSC
12352005
Target
MAP4K
Type
Isotope-Labeled Compounds
Related Pathways
MAPK/ERK Pathway
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Solubility
10 mM in DMSO
Smiles
OC([2H])([C@@H](NC1=NC(NC2=CC(C(C)(N3)C)=C(C=C2)C3=O)=NC=C1C4=NN=CO4)C5=CC=C(C=C5)F)[2H]
Molecular Formula
C24H20D2FN7O3
Molecular Weight
477.49
References & Citations
[1] Jing Ai, et al. Design, Synthesis, and Pharmacological Evaluation of Isoindoline Analogues as New HPK1 Inhibitors. Journal of Medicinal Chemistry. 2023, Article ASAP.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Frequently Asked Questions
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