BET-IN-20
Product Specifications
UNSPSC Description
BET-IN-20 (compound 10) is an inhibitor of BRD4 BD1 (IC50=1.9 nM) with anticancer activity. BET-IN-20 can promote acute myeloid leukemia (AML) cell apoptosis and arrest the cell cycle in the G0/G1 phase. BET-IN-20 also inhibits c-Myc and CDK6 and enhances PARP cleavage[1].
Target Antigen
Apoptosis; Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Apoptosis;Epigenetics
Applications
Cancer-programmed cell death
Field of Research
cancer
Assay Protocol
https://www.medchemexpress.com/bet-in-20.html
Solubility
10 mM in DMSO
Smiles
C[C@H](C1=CC=CC=C1)N2C(C3=C4)=C(N=C2C)C=NC3=CC(C5=C(C)ON=C5C)=C4OC
Molecular Weight
412.48
References & Citations
[1]Yu S et al. Discovery of (R)-4-(8-methoxy-2-methyl-1-(1-phenylethy)-1H-imidazo [4, 5-c] quinnolin-7-yl)-3, 5-dimethylisoxazole as a potent and selective BET inhibitor for treatment of acute myeloid leukemia (AML) guided by FEP calculation[J]. European Journal of Medicinal Chemistry, 2023: 115924.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-149735/BET-IN-20-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-149735/
Clinical Information
No Development Reported
CAS Number
1300735-76-5
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