Thianthrene

Thianthrene is a potent and orally active inhibitor of Leishmania donovani pteridine reductase 1 (PTR1) . Thianthrene is a sulfur-containing tricyclic molecule distributed widely within the macro-structure of hydrocarbon fossil fuels. Thianthrene inhibits the intracellular amastigotes of Leishmania donovani (IC50 = 23 μM) . Thianthrene has a moderate anthelmintic activity. Thianthrene appears to inhibit RNA function and subsequent protein production. Thianthrene can stimulate liver regeneration in vivo[1][2].

Product Specifications

CAS Number

[92-85-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Biochemical Assay Reagents; Parasite

Type

Reference compound

Related Pathways

Anti-infection; Others

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/thianthrene.html

Purity

99.99

Solubility

DMSO : 11.11 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C12=CC=CC=C1SC3=C(C=CC=C3)S2

Molecular Formula

C12H8S2

Molecular Weight

216.33

Precautions

H302, H315, H319, H335

References & Citations

[1]Mitchell SC, et al. Fate of thianthrene in biological systems. Xenobiotica. 2017 Aug;47 (8) :731-740. |[2]Jaspreet Kaur, et al., (2021), Thianthrene is a novel inhibitor of Leishmania donovani pteridine reductase 1 (PTR1) Journal of Molecular Biochemistry